This investigation aims to study the characteristics and release properties of lutein-loaded\npolyvinyl alcohol/sodium alginate (PVA/SA) nanofibers prepared by electrospinning. In order\nto increase PVA/SA nanofibersâ?? water-resistant ability for potential biomedical applications,\nthe electrospun PVA/SA nanofibers were cross-linked with a mixture of glutaraldehyde and\nsaturated boric acid solution at room temperature. The nanofibers were characterized using scanning\nelectron microscopy (SEM) and X-ray diffractometer (XRD). Disintegration time and contact angle\nmeasurements testified the hydrophilicity change of the nanofibers before and after cross-linking.\nThe lutein release from the nanofibers after cross-linking was measured by an ultraviolet absorption\nspectrophotometer, which showed sustained release up to 48 h and followed anomalous (non-Fickian)\nrelease mechanism as indicated by diffusion exponent value obtained from the Korsmeyer-Peppas\nequation. The results indicated that the prepared lutein-loaded PVA/SA nanofibers have great\npotential as a controlled release system.
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